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Key Documents

SML0711

Sigma-Aldrich

RS504393

≥98% (HPLC)

Synonym(e):

6-Methyl-1′-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4′-piperidin]-2(1H)-one, RS-504393

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About This Item

Empirische Formel (Hill-System):
C25H27N3O3
CAS-Nummer:
300816-15-3
Molekulargewicht:
417.50
UNSPSC-Code:
51111800
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 1 mg/mL, clear (warmed)

Lagertemp.

2-8°C

InChI

1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

InChIKey

ODNICNWASXKNNQ-UHFFFAOYSA-N

Anwendung

RS504393 has been used in mass spectrometry.

Biochem./physiol. Wirkung

RS504393 helps to increase the analgesic potency of morphine and buprenorphine in neuropathic rats. RS504393 has the ability to block the upregulation of pronociceptive factors, like IL-1 (interlukin 1) β, IL-18 (interlukin 18), IL-6 (interlukin 6) and inducible nitric oxide synthase (iNOS), that are induced by chronic constriction injury (CCI).
RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.

Leistungsmerkmale und Vorteile

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis
Winter C, et al.
Cell Metabolism (2018)
The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
Kwiatkowski K, et al.
Journal of Neuroimmune Pharmacology, 12(3), 402-419 (2017)
Bradley W Richmond et al.
Mucosal immunology, 14(2), 431-442 (2020-09-25)
Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption
Maira Licia Foresti et al.
Epilepsy & behavior : E&B, 102, 106695-106695 (2019-12-01)
Neuroinflammation role on epileptogenesis has been the subject of increasing interest. Many studies showed elevation in cytokines and chemokines expression following seizures, such as, CCL2 protein (C-C motif ligand 2 chemokine) and its specific receptor, CCR2. In addition, recent studies

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