SML0471

A22 hydrochloride

≥95% (HPLC)

• Synonym(e): MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
• Empirische Formel (Hill-System): C₈H₈Cl₂N₂S · HCl
• CAS-Nummer: 22816-60-0
• Molekulargewicht: 271.59
• MDL-Nummer: MFCD00035050
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825427
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL (clear solution, warmed)
• Lagertemp.: 2-8°C
• SMILES String: Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
• InChI: 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
• InChIKey: VBJNMXMOMSWRDV-UHFFFAOYSA-N

Beschreibung

Anwendung

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

Biochem./physiol. Wirkung

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable