SAB5700317

Anti-Phospho-MDM2-S166 antibody produced in rabbit

• Synonym(e): ACTFS, HDMX, MDM2, hdm2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 11-14; 24-55
• Speziesreaktivität: rat, mouse, human
• Konzentration: 0.63 mg/ml
• Methode(n): immunofluorescence: 1:50-1:100; western blot: 1:500-1:1000
• UniProt-Hinterlegungsnummer: Q00987
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer166)
• Angaben zum Gen: human ... MDM2(4193)

Beschreibung

Allgemeine Beschreibung

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Immunogen

A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).

Physikalische Form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Lagerung und Haltbarkeit

Store at -20℃. Avoid freeze / thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable