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SAB4501162

Sigma-Aldrich

Anti-Glial Fibrillary Acidic Protein Antibody

rabbit polyclonal

Synonym(e):

Glial fibrillary acidic protein

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Produktbezeichnung

Anti-GFAP antibody produced in rabbit, affinity isolated antibody

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 49 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GFAP(2670)

Allgemeine Beschreibung

Anti-GFAP Antibody detects endogenous levels of total GFAP protein.
Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein found in the astrocytes of CNS (central nervous system). It is located on human chromosome 17q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human GFAP.

Immunogen Range: 11-60

Anwendung

Anti-GFAP, N-Terminal antibody has been used in immunocytochemical analysis , confocal and fluorescent microscopic imaging , immunostaining and western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem./physiol. Wirkung

Glial fibrillary acidic protein (GFAP) regulates intermediate filament network dynamics, cell morphology and focal adhesions.It helps in maintaining myelination and stability of CNS (central nervous system) white matter architecture.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke
Tseng KY, et al.
Molecular Therapy (2017)
GFAP promoter directs astrocyte-specific expression in transgenic mice
Brenner M, et al.
The Journal of Neuroscience (1994)
Ayat I Samra et al.
Biomedicines, 11(12) (2023-12-23)
Autism spectrum disorder (ASD) prevalence is emerging with an unclear etiology, hindering effective therapeutic interventions. Recent studies suggest potential renin-angiotensin system (RAS) alterations in different neurological pathologies. However, its implications in ASD are unexplored. This research fulfills the critical gap
Suppression of agrin-22 production and synaptic dysfunction in Cln1 (-/-) mice
Peng S, et al.
Annals of Clinical and Translational Neurology, 2, 1085-1104 (2015)
Childhood constipation; an overview of genetic studies and associated syndromes
Peeters B, et al.
Best Practice & Research. Clinical Gastroenterology, 25 (2011)

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