G6171

Anti-Glial Fibrillary Acidic Protein Antibody

mouse monoclonal, G-A-5

• Synonym(e): Anti-GFAP
• MDL-Nummer: MFCD00145904
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• product name: Anti-Glial Fibrillary Acidic Protein antibody, Mouse monoclonal, clone G-A-5, purified from hybridoma cell culture
• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified from hybridoma cell culture; purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: G-A-5, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~50 kDa
• Speziesreaktivität: rat, human, pig
• Konzentration: ~1.0 mg/mL
• Methode(n): immunocytochemistry: suitable; immunohistochemistry: suitable; indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.; western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P14136
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... GFAP(2670) ; mouse ... Gfap(14580) ; pig ... GFAP(396562) ; rat ... Gfap(24387)

Beschreibung

Allgemeine Beschreibung

Glial fibrillary acidic protein (GFAP) is intermediary filament present in astrocyte cells and is expressed in 10 different isoforms. It comprises of N-terminal head, central rod and C-terminal tail domains. GFAP is mapped to human chromosome 17q21.31.

Immunogen

purified GFAP from pig spinal cord.

Anwendung

Anti-Glial Fibrillary Acidic Protein antibody, Mouse monoclonal has been used in immunocytochemistry and in immunofluorescence.

Monoclonal Anti-Glial Fibrillary Acidic Protein antibody is suitable for use in western blot and indirect immunofluorescence 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum). The antibody can also be used for immunoblot (approx. 50 kDa), immunohistochemistry (in paraformaldehyde-fixed, frozen rabbit brain sections) and immunocytochemistry.

Biochem./physiol. Wirkung

Glial fibrillary acidic protein or GFAP assembly has been implicated in mitotic remodeling of glial structures. Genetic mutations in GFAP have been associated with Alexander disease.

Microdeletion in glial fibrillary acidic protein (GFAP) gene locus is implicated in intellectual disability and facial dysmorphism in children. High levels of GFAP is associated with acute intracerebral haemorrhage.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable