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Merck

SAB4200283

Sigma-Aldrich

Anti-Tensin 1 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Synonym(e):

Anti-TNS1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Konjugat:
unconjugated
application:
IF
IHC
WB
Klon:
polyclonal
Speziesreaktivität:
rat, human, chicken
citations:
12
Methode(n):
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded rat heart.
indirect immunofluorescence: 3-6 μg/mL using chicken embryo fibroblast cells.
western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human tensin 1
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Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 225 kDa (rat)
antigen ~150 kDa (human)

Speziesreaktivität

rat, human, chicken

Erweiterte Validierung

recombinant expression
Learn more about Antibody Enhanced Validation

Konzentration

~1.0 mg/mL

Allgemeine Beschreibung

Tensin 1 (TNS1) is encoded by the gene mapped to human chromosome 2q35. The encoded protein is localized to focal adhesions and is mainly expressed in renal tubular epithelial cells (TECs).

Immunogen

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Anwendung

Anti-Tensin 1 antibody may be used in immunofluorescence and immunohistochemistry.
Anti-Tensin 1 antibody produced in rabbit has been used in immunostaining and immunoblotting.[1][2]

Biochem./physiol. Wirkung

Tensin 1 (TNS1) contributes to transforming growth factor (TGF)-β-induced myofibroblast differentiation and extracellular fibronectin and collagen matrix formation. Disruption in the gene and associated signaling might hinder tissue fibrosis. The encoded protein anchors to stress fibers by interacting with cytoplasmic tails of integrins and increases metastatic abilities of cancer cells. Tensin plays a vital role in activation of the c-Jun N-terminal kinases (JNK) and p38 pathways.
Tensin 1 associates with actin, integrin, FAK, p130Cas, DLC-1 and protein phosphatase PP1 which affects cell polarization, migration and invasion. Tensin 1 undergoes extensive Ser/Thr and Tyr phosphorylation induced by extracellular matrix (ECM), various growth factors and oncogenes. In addition, tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Tensin
Lo S H
The International Journal of Biochemistry & Cell Biology, 36(1), 31-34 (2004)
Tensin is potentially involved in extracellular matrix production in mesangial cells.
Yamashita M
Histochemistry and Cell Biology, 121, 245-254 (2004)
Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation.
Bernau K
American Journal of Respiratory Cell and Molecular Biology, 56, 465-476 (2017)
Tensin can induce JNK and p38 activation.
Katz BZ
Biochemical and Biophysical Research Communications, 272, 717-720 (2000)
Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Dina C
Nature Genetics, 47, 1206?1211-1206?1211 (2015)

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