SAB4200178

Anti-Importin 5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(e): Anti-IPO5, Anti-KPNB3, Anti-importin subunit beta-3, Anti-karyopherin beta-3
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~123 kDa
• Speziesreaktivität: human
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells.; indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293T cells overexpressing human Importin 5.; western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
• UniProt-Hinterlegungsnummer: O00410
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IPO5(3843)

Beschreibung

Allgemeine Beschreibung

Importin 5 (IPO5) is encoded by the gene mapped to human chromosome 13q32.2. The encoded protein belongs to the importin β family. It is primarily expressed in cytoplasm, specifically in the nuclear pore complex.

Anwendung

Anti-Importin 5 (N-terminal) antibody produced in rabbit has been used in western blotting, immunoprecipitation and immunofluorescence.

Biochem./physiol. Wirkung

Importin 5 (IPO5) in association with nucleoside triphosphates and the small GTP binding protein Ran, facilitates migration of nuclear localization signal (NLS)-containing cargo from cytoplasm to nucleus. IPO5 also plays a vital role in apolipoprotein A-1 excretion and also helps in transport of lipids from peripheral tissues via reverse cholesterol transport pathway. Additionally, the encoded protein facilitates transport of ribosomal proteins and core histones into the nucleus. Mutation in the gene is associated with the development of schizophrenia.

Importin 5 (also known as IPO5, karyopherin β-3, importin subunit β-3, KPNB3 and RANBP5) has been identified as an importin for histones and proteins L23a, S7, and L5, and also to the PB1 subunit of the influenza A virus RNA-dependent RNA polymerase.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable