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Key Documents

SAB1305554

Sigma-Aldrich

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse

clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

Synonym(e):

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

137CT26.1.1, monoclonal

Form

buffered aqueous solution

Mol-Gew.

41737 Da

Speziesreaktivität

mouse, human

Methode(n)

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

NP_001092.1

UniProt-Hinterlegungsnummer

P60709

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ACTB(60)

Allgemeine Beschreibung

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Anwendung

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Biochem./physiol. Wirkung

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Physikalische Form

Supplied in PBS with 0.09% (W/V) sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
Ioannis Panagopoulos et al.
Anticancer research, 40(3), 1239-1245 (2020-03-07)
Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. Cytogenetic, fluorescence in situ
Vincent Procaccio et al.
American journal of human genetics, 78(6), 947-960 (2006-05-11)
Actin, one of the major filamentous cytoskeletal molecules, is involved in a variety of cellular functions. Whereas an association between muscle actin mutations and skeletal and cardiac myopathies has been well documented, reports of human disease arising from mutations of
Gaëlle Rached et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(6), e2204846-e2204846 (2023-01-17)
Insulin release is tightly controlled by glucose-stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non-selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose-stimulated insulin secretion (GSIS) is studied
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