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S9896

Sigma-Aldrich

Saporin Peptide

lyophilized powder, from Saponaria officinalis seeds

Synonym(e):

Saponin Extract

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About This Item

MDL-Nummer:
MFCD00132219
UNSPSC-Code:
12352202
NACRES:
NA.32

product name

Saporin from Saponaria officinalis seeds, lyophilized powder

Biologische Quelle

plant seeds (Saponaria officinalis)

Qualitätsniveau

200

Assay

10.00-30.00%

Form

lyophilized powder

Zusammensetzung

Protein, ~20% Lowry

Methode(n)

activity assay: suitable

Lagertemp.

2-8°C

Allgemeine Beschreibung

Saporin from Saponaria officinalis seeds has an N-terminal domain which is β-stranded and a C-terminal domain which is α-helical. It is made up of 253 amino acids and has a molecular weight of 28,621Da.

Anwendung

Saporin from Saponaria officinalis seeds has been used to study its antifungal activity against Fusarium verticillioides.

Biochem./physiol. Wirkung

Saporin from Saponaria officinalis seeds is a ribosome inactivating protein. It is used for the preparation of immunoconjugates. It has been shown to induce the formation of micronuclei in cultured human lymphocytes, thereby reducing cell viability and enhancing apoptosis.

Verpackung

Package size based on protein content.

Physikalische Form

Lyophilized powder containing glucose and sodium phosphate buffer salts

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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The amino acid sequence of a ribosome-inactivating protein from Saponaria officinalis seeds.
Maras B
Biochemistry International, 21(5), 831-838 (1990)
Elizabeth S Ingham et al.
The Journal of comparative neurology, 516(2), 125-140 (2009-07-04)
In mammals, non-image-forming visual functions, including circadian photoentrainment and the pupillary light reflex, are thought to be mediated by the combination of rods, cones, and the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs). Although several genetic models have been developed
R Iglesias et al.
FEBS letters, 325(3), 291-294 (1993-07-05)
The type 1 ribosome-inactivating protein (RIP) saporin 5 isolated from seeds of Saponaria officinalis L. strongly inhibited translation carried out by Vicia sativa L. purified ribosomes. The toxin multidepurinated V. sativa rRNA, which upon treatment with acid aniline releases several
The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome.
Savino C
Febs Letters, 470(3), 239-243 (2000)
Analysis of the Sequence Preference of Saporin by Deep Sequencing.
Hauf, et al.
ACS chemical biology, 17, 2619-2630 (2023)
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