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S7947

Sigma-Aldrich

Stattic

≥98% (HPLC), powder

Synonym(e):

6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

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About This Item

Empirische Formel (Hill-System):
C8H5NO4S
CAS-Nummer:
19983-44-9
Molekulargewicht:
211.19
MDL-Nummer:
MFCD00173799
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329824592
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: >20 mg/mL

SMILES String

[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChIKey

ZRRGOUHITGRLBA-UHFFFAOYSA-N

Anwendung

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5

Biochem./physiol. Wirkung

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic is an irreversible STAT3 activation inhibitor.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway
Cheng M, et al.
American Journal of Translational Research, 11(4), 2317-2317 (2019)
Nikolaos Sismanopoulos et al.
PloS one, 7(3), e33271-e33271 (2012-03-14)
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9
Yunbao Pan et al.
PloS one, 8(1), e54565-e54565 (2013-02-06)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are
Jochen Schust et al.
Chemistry & biology, 13(11), 1235-1242 (2006-11-23)
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that transmit signals from the cell membrane to the nucleus. One family member, STAT3, is constitutively activated by aberrant upstream tyrosine kinase activities in a
Karen Kwofie et al.
Respiratory research, 16, 14-14 (2015-04-08)
Regulation of human airway smooth muscle cells (HASMC) by cytokines contributes to chemotactic factor levels and thus to inflammatory cell accumulation in lung diseases. Cytokines such as the gp130 family member Oncostatin M (OSM) can act synergistically with Th2 cytokines
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