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S143

Sigma-Aldrich

(±)-6-Chloro-PB hydrobromide

≥98% (HPLC), solid

Synonym(e):

(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide

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About This Item

Empirische Formel (Hill-System):
C16H16ClNO2 · HBr
CAS-Nummer:
71636-61-8
Molekulargewicht:
370.67
MDL-Nummer:
MFCD00153782
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277934
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Farbe

white to light tan

Löslichkeit

H2O: 1.7 mg/mL
DMSO: >10 mg/mL
ethanol: 6.3 mg/mL

SMILES String

Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3

InChI

1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H

InChIKey

RMIJGBMRNYUZRG-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD1(1812)

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Anwendung

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Biochem./physiol. Wirkung

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.

Vorsicht

Product is air and light sensitive

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

A M Knab et al.
Journal of biological regulators and homeostatic agents, 26(1), 119-129 (2012-04-06)
The genetic factors involved in the regulation of physical activity are not well understood. The dopamine system has been implicated in the control of voluntary locomotion and wheel running (WR) in mice and is thus a likely candidate as a
Giuseppe Gangarossa et al.
Brain structure & function, 218(2), 405-419 (2012-03-29)
Therapeutic agents and drugs of abuse regulate the extracellular signal-regulated kinase (ERK) cascade signaling in the medium-sized spiny neurons (MSNs) of the striatum. However, whether this regulation is associated with specific cortical and thalamic inputs has never been studied. We
K Kawamoto et al.
British journal of pharmacology, 166(2), 788-800 (2011-12-16)
Dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. Spinal reflex
Charles R Gerfen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(28), 7113-7120 (2008-07-11)
Dopamine receptor signaling exhibits prominent plasticity that is important for the pathogenesis of both addictive and movement disorders. Psychoactive stimulants that activate the dopamine D(1) receptor (Drd1a) induce the rapid phosphorylation and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in
P A Johansen et al.
Journal of neural transmission. General section, 86(2), 97-113 (1991-01-01)
The electrophysiological effects of three selective D1 dopamine (DA) receptor agonists, which exhibit different potencies and efficacies for stimulation of adenylate cyclase, were compared in the rat nucleus accumbens (NAc) using single unit recording and microiontophoretic techniques. The partial agonists
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