R8626

Rifamycin SV Natriumsalz

potency: ≥ 900 IU/mg (anhydrous basis)

• Synonym(e): 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl- 21-acetate monosodium salt, Rifamycin SV monosodium salt
• Empirische Formel (Hill-System): C₃₇H₄₆NNaO₁₂
• CAS-Nummer: 14897-39-3
• Molekulargewicht: 719.75
• EG-Nummer: 238-965-7
• UNSPSC-Code: 51283601
• PubChem Substanz-ID: 329824038
• NACRES: NA.76

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Wirksamkeit: ≥ 900 IU/mg (anhydrous basis)
• Löslichkeit: ethanol: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Wirkungsweise: protein synthesis | interferes
• SMILES String: [Na+].CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)cc([O-])c4c3C2=O
• InChI: 1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1
• InChIKey: YVOFSHPIJOYKSH-NLYBMVFSSA-M

Beschreibung

Allgemeine Beschreibung

Chemical structure: macrolide

Anwendung

Rifamycin SV is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group. It is used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B.

Biochem./physiol. Wirkung

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

Verpackung

1g,5g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Air sensitive. Store under inert gas

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)