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PZ0143

Sigma-Aldrich

PF-4708671

≥98% (HPLC)

Synonym(e):

2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

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About This Item

Empirische Formel (Hill-System):
C19H21F3N6
CAS-Nummer:
1255517-76-0
Molekulargewicht:
390.41
MDL-Nummer:
MFCD18086922
UNSPSC-Code:
51111800
PubChem Substanz-ID:
329823728
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

off-white

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

room temp

SMILES String

CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2

InChI

1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)

InChIKey

FBLPQCAQRNSVHB-UHFFFAOYSA-N

Angaben zum Gen

human ... RPS6KB1(6198)
mouse ... Rps6kb1(72508)
rat ... Rps6kb1(83840)

Biochem./physiol. Wirkung

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Leistungsmerkmale und Vorteile

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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