PRS2325

Anti-CASPASE-12 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Casp-12
• MDL-Nummer: MFCD03454856
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: predicted mol wt 46 kDa
• Speziesreaktivität: rat, mouse, human
• Methode(n): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt-Hinterlegungsnummer: O08736
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Casp12(12364)

Beschreibung

Allgemeine Beschreibung

Caspase 12 (CASP12), a member of the caspase family, is expressed in the Golgi complex.

Immunogen

a peptide corresponding to amino acids 2-17 of murine caspase-12.

Anwendung

Anti-CASPASE-12 (ab1) antibody produced in rabbit has been used in western blotting.

Biochem./physiol. Wirkung

Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP2325.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable