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A7655

Sigma-Aldrich

Atenolol

≥98% (TLC), powder, β₁-adrenoceptor antagonist

Synonym(e):

(±)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]-propoxy]-benzolacetamid, 4-[2′-Hydroxy-3′-(isopropylamino)-propoxy]-phenylacetamid

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About This Item

Empirische Formel (Hill-System):
C14H22N2O3
CAS-Nummer:
29122-68-7
Molekulargewicht:
266.34
EG-Nummer:
249-451-7
MDL-Nummer:
MFCD00057645
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277748
NACRES:
NA.77

product name

Atenolol, ≥98% (TLC), powder

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Farbe

white to off-white

Löslichkeit

H2O: 0.3 mg/mL
DMSO: 18 mg/mL
ethanol: 3.4 mg/mL

Ersteller

AstraZeneca

SMILES String

CC(C)NCC(O)COc1ccc(CC(N)=O)cc1

InChI

1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)

InChIKey

METKIMKYRPQLGS-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRB1(153)
rat ... Adrb1(24925)

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Anwendung

Atenolol is a β-adrenergic blocker and used in the management of hypertension. Atenolol has antianginal and antiarrhythmic properties.

Biochem./physiol. Wirkung

Selective β1-adrenoceptor antagonist; antihypertensive; antianginal; antiarrhythmic.

Leistungsmerkmale und Vorteile

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sonstige Hinweise

Shelf-life of the solid is at least three years.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Standard

Produkt-Nr.
Beschreibung
Preisangaben

06613

Atenolol-d7, analytical standard

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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(+/-)-Atenolol

Sigma-Aldrich

5.05416

(+/-)-Atenolol

ICI 118.551 -hydrochlorid ≥98% (HPLC), powder

Sigma-Aldrich

I127

ICI 118.551 -hydrochlorid

Carvedilol ≥98% (HPLC), solid

Sigma-Aldrich

C3993

Carvedilol

Atenolol-d7 analytical standard

Supelco

06613

Atenolol-d7

Nadolol analytical standard

Supelco

N1892

Nadolol

Hsin-Hui Chiu et al.
Mayo Clinic proceedings, 88(3), 271-276 (2013-01-17)
To assess the tolerability and efficacy of the investigational use of the angiotensin II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root dilation in patients with Marfan syndrome (MFS). Between May 1, 2007, and September 31
Ganesha Rai et al.
Journal of medicinal chemistry, 52(20), 6474-6483 (2009-09-19)
Schistosomiasis is a chronic parasitic disease affecting hundreds of millions of individuals worldwide. Current treatment depends on a single agent, praziquantel, raising concerns of emergence of resistant parasites. Here, we continue our explorations of an oxadiazole-2-oxide class of compounds we
Ronald V Lacro et al.
The New England journal of medicine, 371(22), 2061-2071 (2014-11-19)
Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, the current standard therapy in most centers. We conducted a randomized trial comparing
Tzu-Heng Huang et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Thoracic aortic aneurysm (TAA) formation is a multifactorial process that results in diverse clinical manifestations and drug responses. Identifying the critical factors and their functions in Marfan syndrome (MFS) pathogenesis is important for exploring personalized medicine for MFS. Methylenetetrahydrofolate reductase
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American heart journal, 165(5), 828-835 (2013-04-30)
The Pediatric Heart Network designed a clinical trial to compare aortic root growth and other short-term cardiovascular outcomes in children and young adults with Marfan syndrome randomized to receive atenolol or losartan. We report here the characteristics of the screened
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Chromatograms

application for HPLC

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