P8861

Pyrrolnitrin from Pseudomonas cepacia

≥98% (HPLC), solid

• Synonym(e): 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
• CAS-Nummer: 1018-71-9
• EG-Nummer: 213-812-7
• MDL-Nummer: MFCD00865605
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24898985
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: solid
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | inhibits
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: [O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
• InChI: 1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
• InChIKey: QJBZDBLBQWFTPZ-UHFFFAOYSA-N

Beschreibung

Spezifität

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

Anwendung

Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.

Biochem./physiol. Wirkung

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves