P8386

Phenylbutazon

• Synonym(e): 4-Butyl-1,2-diphenyl-3,5-pyrazolidindion
• Empirische Formel (Hill-System): C₁₉H₂₀N₂O₂
• CAS-Nummer: 50-33-9
• Molekulargewicht: 308.37
• EG-Nummer: 200-029-0
• MDL-Nummer: MFCD00005500
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277729
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• mp (Schmelzpunkt): 106-108 °C (lit.)
• Löslichkeit: ethanol: 50 mg/mL, clear, colorless to light yellow
• SMILES String: CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
• InChI: 1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
• InChIKey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP2C9(1559) , PTGIS(5740) , PTGS1(5742) , PTGS2(5743)

Beschreibung

Anwendung

Phenylbutazone has been used:

• as a hepatotoxin in transgenic zebrafish line (LiPan) hepatotoxin assay
• as a standard in high-performance liquid chromatography-ultraviolet (HPLC-UV) method
• as an anti-inflammatory compound in hen′s egg chorioallantoic membrane test (HET-CAM assay)

Biochem./physiol. Wirkung

Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles.

Substrate

Non-steroidal anti-inflammatory compound; inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H312 + H332,H315,H319,H335
• P-Sätze: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves