P6273

2-Propylpentansäure

• Synonym(e): 2-Propylvaleriansäure
• Lineare Formel: (CH₃CH₂CH₂)₂CHCO₂H
• CAS-Nummer: 99-66-1
• Molekulargewicht: 144.21
• EG-Nummer: 202-777-3
• MDL-Nummer: MFCD00002672
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 24898751
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 200
• Brechungsindex: n20/D 1.425 (lit.)
• bp: 220 °C (lit.)
• Löslichkeit: H₂O: slightly soluble; alcohol: soluble
• Dichte: 0.9 g/mL at 25 °C (lit.)
• Lipid-Typ: saturated FAs
• SMILES String: CCCC(C(O)=O)CCC
• InChI: 1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
• InChIKey: NIJJYAXOARWZEE-UHFFFAOYSA-N
• Angaben zum Gen: human ... ALDH5A1(7915) , CYP1A2(1544) ; mouse ... Hdac1(433759) ; rat ... Slc6a1(79212)

Beschreibung

Anwendung

2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.

Biochem./physiol. Wirkung

2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.

Antikonvulsivum, das auch eine Wirkung als Stimmungsstabilisator bei einer bipolaren Störung besitzt.

Sicherheitshinweise

• Piktogramme: GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H315,H318,H360FD
• P-Sätze: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): 231.8 °F - closed cup
• Flammpunkt (°C): 111 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter