P5864
Proteoglycan from bovine nasal septum
chromatographically purified
Synonym(e):
Bovine Proteoglycan, Nasal Proteoglycan
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About This Item
Empfohlene Produkte
Biologische Quelle
bovine nasal septum
Qualitätsniveau
Form
powder
Methode(n)
cell culture | stem cell: suitable
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
bovine ... PRG4(280867)
Allgemeine Beschreibung
Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.
Anwendung
Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture.
Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.
Biochem./physiol. Wirkung
Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.
Angaben zur Herstellung
Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to
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