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P4056
Platelet-Derived Growth Factor-BB from rat
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(e):
PDGF-BB
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About This Item
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Produktbezeichnung
Platelet-Derived Growth Factor-BB from rat, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Rekombinant
expressed in E. coli
Qualitätsniveau
Form
lyophilized powder
Wirksamkeit
1.62 ng/mL EC50
Qualität
endotoxin tested
Mol-Gew.
~30 kDa
Verpackung
pkg of 5x50 μg
pkg of 50 μg
Lagerbedingungen
avoid repeated freeze/thaw cycles
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
≤1 EU/μg
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
rat ... Pdgfb(24628)
Allgemeine Beschreibung
Platelet-derived growth factor (PDGF) is a 30 kDa cationic polypeptide and consists of two disulphide linked chains A and B. PDGF is expressed as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.
Anwendung
Platelet-Derived Growth Factor-BB from rat has been used as a growth supplement in mouse embryonic fibroblast culture, motoneuron-muscle co-culture and adult spinal cord neurons culture.
Biochem./physiol. Wirkung
Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes. PDGF is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF activates smooth muscle relocalization and multiplication. PDGF mediated increased smooth muscle muscle proliferation might be associated with gene regulation. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.
Sonstige Hinweise
Dimer of the B chain of rat PDGF.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 2.5 mg bovine serum albumin.
Hinweis zur Analyse
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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