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O3514
Bovine Osteopontin
from bovine milk, powder, suitable for cell culture
Synonym(e):
Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
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About This Item
Empfohlene Produkte
Produktbezeichnung
Osteopontin from bovine milk, lyophilized powder
Biologische Quelle
bovine milk
Qualitätsniveau
Sterilität
sterile
Form
lyophilized powder
Mol-Gew.
~60 kDa
Verpackung
pkg of 50 μg
Methode(n)
cell culture | mammalian: suitable
Versandbedingung
ambient
Lagertemp.
−20°C
Angaben zum Gen
cow ... SPP1(281499)
Allgemeine Beschreibung
Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.
Biochem./physiol. Wirkung
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.
Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Hinweis zur Analyse
The biological activity is measured by its ability to mediate 293 cell adhesion.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (1999)
Milk and Milk Products in Human Nutrition (2011)
Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6: The products of gene 1 and gene 2 are required for pac cleavage.
Chai S, et al.
Journal of Molecular Biology, 224(1), 87-102 (1992)
Milk Proteins: From Expression to Food (2014)
D D Hu et al.
The Journal of biological chemistry, 270(44), 26232-26238 (1995-11-03)
Osteopontin (OPN) is an extracellular matrix protein that binds to integrin alpha v beta 3. Here we demonstrate that two other integrins, alpha v beta 1 and alpha v beta 5, are also receptors for OPN. Human embryonic kidney 293
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