N7764

Nicotinic acid mononucleotide

• Synonym(e): Nicotinate mononucleotide
• Empirische Formel (Hill-System): C₁₁H₁₄NO₉P
• CAS-Nummer: 321-02-8
• Molekulargewicht: 335.20
• MDL-Nummer: MFCD00070358
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24897839
• NACRES: NA.79

Eigenschaften

• Biologische Quelle: animal
• Qualitätsniveau: 200
• Assay: ≥98.0% (HPLC)
• Form: powder
• Methode(n): HPLC: suitable
• Farbe: white
• Lagertemp.: −20°C
• SMILES String: OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
• InChI: 1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
• InChIKey: IUJWGLOJJKFASX-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Nicotinic acid mononucleotide (NaMN) is formed from nicotinic acid 5-phosphoribosyl-1-pyrophosphate (PRPP) in the Preiss-Handler pathway in the presence of enzyme phosphoribosyltransferase (NaPRT).

Anwendung

Nicotinic acid mononucleotide has been used as a substrate for NMN/NaMN adenylyltransferase (NMNAT) during nicotinamide adenine dinucleotide (NAD) biosynthesis.

Biochem./physiol. Wirkung

Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast. Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT) and nicotinate mononucleotide adenylyltransferase. NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)