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MAK157

Sigma-Aldrich

Renin Assay Kit

sufficient for 100 fluorometric tests

Synonym(e):

Renin Enzyme Detection Kit

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About This Item

UNSPSC-Code:
12161503
NACRES:
NA.84

Verwendung

sufficient for 100 fluorometric tests

Nachweisverfahren

fluorometric

Relevante Krankheit(en)

cardiovascular diseases

Lagertemp.

−20°C

Angaben zum Gen

human ... REN(5972)
rat ... REN(24715)

Verwandte Kategorien

Allgemeine Beschreibung

Renin, also known as angiotensinogenase, is an aspartyl protease that cleaves angiotensinogen to form angiotensin I, the initial and rate-limiting step of the renin-angiotensin system (RAS). This system plays a critical role in the regulation of blood pressure and fluid balance. Increased renin activity can result in hypertension due to increased vasoconstriction and fluid retention. Inhibitors of renin can be used as a treatment for hypertension.

Anwendung

Renin Assay Kit has been used to determine the activity of renin.

Eignung

The Renin Assay Kit provides a convenient and simple method for screening renin activity in a variety of samples or for screening renin inhibitors.

Prinzip

Renin activity is determined using a proprietary fluorescence resonance energy transfer (FRET) peptide containing a fluorescence quencher. Cleavage of the peptide by renin results in the production of a fluorescent product (λex = 540/λem = 590 nm). This assay is ~50-fold more sensitive than the EDANS/DABCYL-based assay.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Yoshio T, et al.
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research (2015)
Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells.
Sim?o S, et al.
Angiogenesis, 20(1), 175-181 (2017)
The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol.
Song P, et al.
Cell Metabolism, 27(6), 1338-1347 (2018)
Árpád Kovács et al.
American journal of physiology. Heart and circulatory physiology, 310(11), H1671-H1682 (2016-04-10)
Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured.
Caroline G Shimoura et al.
Journal of applied physiology (Bethesda, Md. : 1985), 128(5), 1329-1337 (2020-04-03)
Acute intermittent hypoxia (AIH) triggers sympathetic long-term facilitation (sLTF), a progressive increase in sympathetic nerve activity (SNA) linked to central AT1 receptor (AT1R) activation by circulating angiotensin II (ANG II). Here, we investigated AIH activation of the peripheral renin-angiotensin system
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