M9429

Menadion

meets USP testing specifications

• Synonym(e): 2-Methyl-1,4-naphthochinon, Vitamin K₃
• Empirische Formel (Hill-System): C₁₁H₈O₂
• CAS-Nummer: 58-27-5
• Molekulargewicht: 172.18
• Beilstein: 1908453
• EG-Nummer: 200-372-6
• MDL-Nummer: MFCD00001681
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 24897335
• NACRES: NA.21

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Agentur: USP/NF; meets USP testing specifications
• Assay: 98.5-101.0% dry basis
• Form: solid
• mp (Schmelzpunkt): 105-107 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: CC1=CC(=O)c2ccccc2C1=O
• InChI: 1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
• InChIKey: MJVAVZPDRWSRRC-UHFFFAOYSA-N
• Angaben zum Gen: human ... NQO1(1728)

Beschreibung

Allgemeine Beschreibung

Menadione (Vitamin K3) is the synthetic form of vitamin K. It has the structure similar to vitamin K1 and K2. Vitamin K1, K2 and K3 are biologically active. Water soluble forms of menadiones are used in swine and poultry diets.

Anwendung

Menadione has been used:

• to treat HL-60 cells as positive control for apoptosis for flow cytometry
• as an oxidative stress inducer in transgenic embryos after 24 h of post fertilization
• to treat HaCaT cell line, for quantifying total and oxidised glutathione

Biochem./physiol. Wirkung

Menadione is an oxidative stress inducer.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H315,H317,H319,H335,H410
• P-Sätze: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves