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M1275

Sigma-Aldrich

Naproxen Natrium

98.0-102.0%

Synonym(e):

(S)-6-Methoxy-α-methyl-2-naphthalinessigsäure Natriumsalz

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About This Item

Empirische Formel (Hill-System):
C14H13NaO3
CAS-Nummer:
26159-34-2
Molekulargewicht:
252.24
EG-Nummer:
247-486-2
MDL-Nummer:
MFCD00058507
UNSPSC-Code:
12352200
PubChem Substanz-ID:
57654352
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

98.0-102.0%

Form

powder

Löslichkeit

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

Ersteller

Bayer

SMILES String

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChIKey

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Angaben zum Gen

human ... PTGS1(5742) , PTGS2(5743)

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Allgemeine Beschreibung

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Anwendung

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Biochem./physiol. Wirkung

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.
Cyclooxygenase (Prostaglandin H-Synthase 1 und 2)-Hemmer.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

H-Sätze

H302,H360

Gefahreneinstufungen

Acute Tox. 4 Oral - Repr. 1A

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Jing Xia et al.
Plant communications, 4(6), 100632-100632 (2023-05-31)
The phytohormone auxin plays central roles in many growth and developmental processes in plants. Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture. Here we reveal that naproxen, a synthetic compound with anti-inflammatory
Binding thermodynamics of Diclofenac and Naproxen with human and bovine serum albumins: A calorimetric and spectroscopic study
Bou-Abdallah F, et al.
The Journal of Chemical Thermodynamics, 103, 299-309 (2016)
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which
Flores Martín-Reyes et al.
Antioxidants (Basel, Switzerland), 12(12) (2023-12-23)
Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms in genes related to autophagy and the consumption
Arın Gül Dal et al.
Journal of analytical methods in chemistry, 2014, 352698-352698 (2014-10-09)
Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10%
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Chromatograms

application for HPLC

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