K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• Synonym(e): K-252a
• Empirische Formel (Hill-System): C₂₇H₂₁N₃O₅
• CAS-Nummer: 99533-80-9
• Molekulargewicht: 467.47
• EG-Nummer: 200-664-3
• MDL-Nummer: MFCD00161522
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329817131
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: Nonomuraea longicatena
• Qualitätsniveau: 200
• Assay: >98%
• Form: solution
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChIKey: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Angaben zum Gen: human ... NTRK1(4914) ; rat ... Prkca(24680)

Beschreibung

Biochem./physiol. Wirkung

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Leistungsmerkmale und Vorteile

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physikalische Form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): 188.6 °F - closed cup
• Flammpunkt (°C): 87 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)