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I6137
Monoclonal Anti-Bovine IgM antibody produced in mouse
clone BM-23, ascites fluid
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About This Item
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
ascites fluid
Antikörper-Produkttyp
secondary antibodies
Klon
BM-23, monoclonal
Enthält
15 mM sodium azide
Methode(n)
capture ELISA: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:4,000
western blot: suitable
Isotyp
IgG1
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Allgemeine Beschreibung
Bovine IgMs are glycoprotein antibodies that regulate antigen binding during immunological responses. These antibodies have three isotypes, namely, IgMa, IgMb and IgMc. Structural restraints on movement enhance the complement-fixing functions of bovine IgMs . Monoclonal Anti-Bovine IgM antibody detects an epitope on the heavy chain of bovine IgM. The antibody reacts with bovine serum, but does not react with sera from human, baboon, marmoset, gibbon, rhesus, hamster, rabbit, goat, pig, dog, rat, turkey, chicken, or catfish. Furthermore, the product does not bind to native or reduced bovine light chains.
Monoclonal Anti-Bovine IgM (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgM is highly conserved antibody in vertebrates and is expressed early during immune response. It exists as pentamer and is secreted by peritoneal B cells.
Immunogen
Purified bovine IgM
Anwendung
Monoclonal Anti-Bovine IgM antibody is suitable for use in indirect ELISA (1:1,000), western blot, immunoprecipitation and ELISA.
Biochem./physiol. Wirkung
IgM plays a key role in engulfing of the of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Amy S Austin et al.
Journal of immunology (Baltimore, Md. : 1950), 171(3), 1336-1342 (2003-07-23)
IgA is the predominant Ig isotype in mucosal secretions and thus plays a pivotal role in host defense. The mechanisms by which IgA expression is regulated may differ among species and involve multiple pathways. Various cytokines and costimulators have been
Escherichia coli O157: H7 and other Shiga toxin-producing E. coli in white veal calves
Cristancho L, et al.
Veterinary Microbiology, 126, 200-209 (2008)
Hilary E Kennedy et al.
Infection and immunity, 70(3), 1488-1500 (2002-02-21)
It is accepted that cell-mediated immune responses predominate in mycobacterial infections. Many studies have shown that CD4(+) T cells produce Th1 cytokines, such as gamma interferon (IFN-gamma), in response to mycobacterial antigens and that the cytolytic activity of CD8(+) cells
Surinder S Saini et al.
International immunology, 15(7), 845-853 (2003-06-17)
Naturally occurring antibody repertoires of cattle (Bos taurus) include a group of IgMlambda antibodies with exceptionally long complementarity-determining region 3 of the heavy chain (CDR3H) segments, containing multiple Cys residues. These massive CDR3H segments will greatly influence the tertiary and
S S Saini et al.
Molecular immunology, 38(5), 389-396 (2001-10-31)
The structure of IgM determined from two cDNAs isolated from a Holstein (BLV7G1) and an Angus x Hereford cross-bred (B5D8) cow reveals high sequence similarity both at nucleotide (98.7%) and amino acid (97.9%) level and is closest to sheep (89.4%).
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