H0266
Hemoglobin A2, Ferrous Stabilized human
lyophilized powder
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About This Item
CAS-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
eCl@ss:
42030116
NACRES:
NA.61
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Assay
97-100% (agarose gel electrophoresis)
Form
lyophilized powder
Methode(n)
immunofluorescence: suitable
Eignung
suitable for electrophoresis and chromatography standard
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... HBA2(3040)
Allgemeine Beschreibung
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).
Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
Anwendung
Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.
Biochem./physiol. Wirkung
Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.
Verpackung
Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).
Rekonstituierung
When reconstituted with buffer, gives >90% ferrous hemoglobin.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Domenico Dell'Edera et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 26(5), 445-448 (2012-10-09)
This research, conducted on 1495 couples in preconceptional period, demonstrates how the study of globular resistance of erythrocytes (GRO) is not a first choice test and not useful as other more accurate tests to identify subjects with β-thalassemia trait. Instead
Dominant β-thalassemia - a rare entity!
Rachna Khera et al.
Indian journal of pathology & microbiology, 55(3), 422-423 (2012-10-04)
Stacy Colaco et al.
Clinica chimica acta; international journal of clinical chemistry, 413(19-20), 1705-1707 (2012-06-05)
An increased HbA2 level is the hallmark for identification of β thalassemia carriers. However, in some carriers the level of HbA2 is not typically elevated creating difficulties in making a diagnosis. We describe a family having an affected child referred
Alauddin Hafiza et al.
The Malaysian journal of pathology, 34(2), 161-164 (2013-02-22)
The capillary electrophoresis (CE) is a new system that utilizes the principle of electrokinetic separation of molecules in eight electrolyte buffer-filled silica capillaries. In this study, we established the normal ranges of haemoglobin A2 (HbA2) and haemoglobin F (HbF) levels
Hb Dartmouth (HBA2: c. 200T> C): An alpha2-globin gene associated with Hb H disease in one homozygous patient
Farashi S, et al.
Hemoglobin, 39(3), 152-155 (2015)
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