F8557

FK866 hydrochloride hydrate

≥98% (HPLC), powder, NAD biosynthesis inhibitor

• Synonym(e): FK866 hydrochloride hydrate, (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, K22.175
• Empirische Formel (Hill-System): C₂₄H₂₉N₃O₂·HCl · xH₂O
• CAS-Nummer: 658084-64-1
• Molekulargewicht: 427.97 (anhydrous basis)
• MDL-Nummer: MFCD10565943
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: FK866 hydrochloride hydrate, ≥98% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: N2(CCC(CC2)CCCCNC(=O)\C=C\c3cnccc3)C(=O)c1ccccc1
• InChI: 1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
• InChIKey: KPBNHDGDUADAGP-VAWYXSNFSA-N

Beschreibung

Allgemeine Beschreibung

FK866 is used to treat inflammatory diseases and cancer.

Anwendung

FK866 hydrochloride hydrate has been used:

• to investigate its effects on intra-axonal NAD⁺ levels
• to induce NAD+ depletion
• to reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue

Biochem./physiol. Wirkung

FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable