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E4660

Sigma-Aldrich

Eupatorin

≥97% (HPLC)

Synonym(e):

3′,5-Dihydroxy-4′,6,7-trimethoxy-flavon, 5-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-6,7-dimethoxy-4H-1-benzopyran-4-on, 6-Methoxy-luteolin-4′,7-dimethylether, NSC 106402

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About This Item

Empirische Formel (Hill-System):
C18H16O7
CAS-Nummer:
855-96-9
Molekulargewicht:
344.32
MDL-Nummer:
MFCD00016929
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329799061
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥97% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

room temp

SMILES String

COc1ccc(cc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI

1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

InChIKey

KLAOKWJLUQKWIF-UHFFFAOYSA-N

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Anwendung

Eupatorin has been used as reference standard for characterization of Artemisia extracts using mass spectrometry (MS).

Biochem./physiol. Wirkung

Eupatorin acts as an antiproliferative in cells expressing the CYP1A- family. It induces G2/M block follow by apoptosis in cells expressing the CYP1A- family. It also functions as an anti-inflammatory.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Hymecromon European Pharmacopoeia (EP) Reference Standard

Y0000011

Hymecromon

Iva Dolečková et al.
Fitoterapia, 83(6), 1000-1007 (2012-06-16)
Flavone eupatorin is one of the constituents of Orthosiphon stamineus, a medicinal herb used in folk medicine in South East Asia for treatment of various disorders. In our study, we investigated the antiproliferative properties of a chloroform extract of the
Yit Hong Loon et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 816(1-2), 161-166 (2005-01-25)
A simple liquid chromatographic method was developed for the simultaneous determination of flavonoids from Orthosiphon stamineus Benth, namely sinensitin, eupatorin and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone, in plasma. Prior to analysis, the flavonoids and the internal standard (naproxen) were extracted from plasma samples using
Nursyamirah Abd Razak et al.
Integrative cancer therapies, 19, 1534735420935625-1534735420935625 (2020-08-25)
Eupatorin is a polymethoxy flavone extracted from Orthosiphon stamineus and was reported to exhibit cytotoxic effects on several cancer cell lines. However, its effect as an anti-breast cancer agent in vivo has yet to be determined. This study aims to
Mirka Laavola et al.
Planta medica, 78(8), 779-786 (2012-04-21)
Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for anti-inflammatory drug development. Orthosiphon stamineus
Mun Fei Yam et al.
Journal of acupuncture and meridian studies, 5(4), 176-182 (2012-08-18)
Orthosiphon stamineus extracts contain three flavonoids (3'-hydroxy-5,6,7,4'-tetramethoxyflavone, sinensetin, and eupatorin) as bioactive substances. Previous reported high performance liquid chromatography- ultraviolet (HPLC-UV) methods for the determination of these flavonoids have several disadvantages, including unsatisfactory separation times and not being well validated
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