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D9378

Sigma-Aldrich

3,4-Dihydroxy-D-Phenylalanin

≥95% (TLC), powder, DOPA enantiomer

Synonym(e):

3-(3,4-Dihydroxyphenyl)-D-alanin, D-DOPA

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About This Item

Empirische Formel (Hill-System):
C9H11NO4
CAS-Nummer:
5796-17-8
Molekulargewicht:
197.19
Beilstein:
2417637
EG-Nummer:
227-343-0
MDL-Nummer:
MFCD00063061
UNSPSC-Code:
12352209
eCl@ss:
32160406
PubChem Substanz-ID:
24894286
NACRES:
NA.32

product name

3,4-Dihydroxy-D-Phenylalanin, powder, ≥95%

Qualitätsniveau

100

Assay

≥95%

Form

powder

mp (Schmelzpunkt)

276-278 °C (lit.)

Löslichkeit

1 M HCl: soluble
ethanol: insoluble

Lagertemp.

−20°C

SMILES String

N[C@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m1/s1

InChIKey

WTDRDQBEARUVNC-ZCFIWIBFSA-N

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Anwendung

3,4-Dihydroxy-D-phenylalanine has been used as a standard in high-performance liquid chromatography (HPLC) analysis of L-DOPA extracted from both germinated and raw seed flours of velvet bean.

Biochem./physiol. Wirkung

3,4-Dihydroxy-D-phenylalanine (D-DOPA) is a DOPA enantiomer. It exhibits antimicrobial activity. D-DOPA serves as a precursor for dopamine.

Sonstige Hinweise

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Tomoya Kawazoe et al.
Chemical record (New York, N.Y.), 7(5), 305-315 (2007-10-10)
The flavoprotein D-amino acid oxidase (DAO) degrades the gliotransmitter D-Ser, a potent activator of N-methyl-D-aspartate-type glutamate receptors. A body of evidence suggests that DAO, together with its activator, G72 protein, may play a key role in the pathophysiology of schizophrenia.
Nan Lu et al.
Electrophoresis (2020-09-20)
This review summarizes recent developments (over the past decade) in the field of microfluidics-based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed.
Mark H Burrell et al.
ACS chemical neuroscience, 6(11), 1802-1812 (2015-09-01)
Tonic dopamine (DA) levels influence the activity of dopaminergic neurons and the dynamics of fast dopaminergic transmission. Although carbon fiber microelectrodes and fast-scan cyclic voltammetry (FSCV) have been extensively used to quantify stimulus-induced release and uptake of DA in vivo
Anthony Bertucci et al.
Bioorganic & medicinal chemistry, 18(6), 2300-2303 (2010-02-24)
The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K(A) in
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 17(15), 4107-4112 (2007-06-02)
An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by L-/D-His, dopamine and serotonin (K(A)s of
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