D2625

5-Dimethylamino-1-naphthalinsulfonylchlorid

BioReagent, suitable for amino acid labeling, powder and chunks, ≥99% (HPLC)

• Synonym(e): DNSCl, Dansylchlorid
• Empirische Formel (Hill-System): C₁₂H₁₂ClNO₂S
• CAS-Nummer: 605-65-2
• Molekulargewicht: 269.75
• Beilstein: 2217205
• EG-Nummer: 210-092-6
• MDL-Nummer: MFCD00003985
• UNSPSC-Code: 12352101
• PubChem Substanz-ID: 24893700
• NACRES: NA.26

Eigenschaften

• Produktlinie: BioReagent
• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder and chunks
• Farbe: yellow to yellow-orange
• mp (Schmelzpunkt): 72-74 °C (lit.)
• Löslichkeit: acetone: 20 mg/mL
• Eignung: suitable for amino acid labeling
• Lagertemp.: 2-8°C
• SMILES String: CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
• InChI: 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
• InChIKey: XPDXVDYUQZHFPV-UHFFFAOYSA-N

Beschreibung

Anwendung

Dansyl chloride has been used:

• as a fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase high performance liquid chromatography (HPLC)
• in the derivatization of plasma samples
• in the quantification of immobilized alkaline phosphatase

Ein fluorogenes Reagens für die N-terminale Derivatisierung von Aminosäuren und Peptiden und die Detektion durch Umkehrphasen-HPLC.

Biochem./physiol. Wirkung

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H290,H314
• P-Sätze: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges