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Merck

B2680

Sigma-Aldrich

BMP4, human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(e):

BMP-4

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352202
NACRES:
NA.32

product name

Bone Morphogenetic Protein 4 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in NSO cells

Assay

>95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

10-30 ng/mL ED50

Mol-Gew.

monomer calculated mol wt 13 kDa
~22 kDa by SDS-PAGE

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

<1 EU/mg Endotoxin level (LAL test)

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

human ... BMP4(652)

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Biochem./physiol. Wirkung

Cellular responses to BMP-4 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF A by osteoblasts. Mature human and mouse BMP-4 demonstrates 98% and 100% homology, respectively, to mature rat BMP-4.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Hinweis zur Analyse

The biological activity is measured by its ability to induce alkaline phosphatase production by C2C12 myoblasts.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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M Kawabata et al.
Cytokine & growth factor reviews, 9(1), 49-61 (1998-08-28)
Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of the transforming growth factor-beta (TGF-beta) superfamily. Activities of BMPs are extracellularly regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of serine-threonine kinase receptors, type
Meike Simann et al.
Bone, 78, 102-113 (2015-05-12)
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Martine M L Deckers et al.
Endocrinology, 143(4), 1545-1553 (2002-03-19)
During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed that vascular endothelial growth factor A (VEGF-A) might be an important factor in this cross-talk, as osteoblast-like cells produce this angiogenic factor
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