A3352
Acyl-Coenzym A-Synthetase aus Pseudomonas sp.
≥2 units/mg protein
Synonym(e):
Acid: CoA ligase (AMP-forming)
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CAS-Nummer:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-747-5
MDL number:
Specific activity:
≥2 units/mg protein
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Unterstützung erhaltenGeneral description
Acyl-coenzyme A synthetase belongs to adenylate-forming enzymes superfamily. It has a conserved adenosine triphosphate/adenosine monophosphate (ATP/AMP) binding motif.
Application
Acyl-coenzyme A Synthetase may be used to study fatty acid metabolism and lipid metabolism. It has been used to study its interaction with fatty acid transport proteins, which has been found to be involved in the efficient cellular uptake of long-chain fatty acids in adipocytes .
Acyl-coenzyme A (coA) synthetase from Pseudomonas sp. has been used:
- as ligase in the synthesis of mevalonate derivatives of adenosine triphosphate (ATP)
- in in vitro fatty acylation assays
- in the synthesis of (14C)Vernoloyl-CoA (Va-CoA),(3) bisphosphonates derivatives of ATP(4) and (3H)Palmitate-CoA
Biochem/physiol Actions
Acyl coenzyme A synthetase proteins are involved in regulating and facilitating long-chain fatty acid transport in mammalian cells .
Acyl-coenzyme A (CoA) synthetase (ACS) enzyme catalyzes a two-step thioesterification reaction involving the conversion of free fatty acids (FAs) to CoA esters. The substrate for ACS varies from two carbon to 26 carbon FAs. It is involved in the activation of FAs for lipid metabolism and enables FA to participate in various cellular metabolic pathways.
Other Notes
1 U bildet 1.0 μmol AMP und Oleoyl-Coenzym A aus ATP und Oleat bei pH 8.1 und 25 °C in Anwesenheit von Coenzym A.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Teresa J Stradomska
Postepy biochemii, 57(2), 183-190 (2011-09-15)
Peroxisomes, classical compartments of eucaryotic cells have significant functions in cellular metabolism, which beta-oxidation fatty acids and detoxification of H2O2 are the most important biochemical process. Defects in genes encoding for peroxisomal proteins result in biochemical malfunctioning of these organelles
A Ruść et al.
Meat science, 89(4), 440-443 (2011-06-10)
The aim of the study was to check whether different genotypes at acyl-CoA synthetase (ACSL4 locus, SNP G2645A) are associated with pork quality. 132 (Landrace × Yorkshire) × Duroc fatteners were genotyped by originally developed PCR-RFLP method. Upon the slaughter
Michael Veit et al.
Methods in molecular biology (Clifton, N.J.), 446, 163-182 (2008-04-01)
Palmitoylation or S-acylation is the post-translational attachment of fatty acids to cysteine residues and is common among integral and peripheral mem brane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3352-10UN | 04061833627624 |
| A3352-5UN | 04061833627662 |
| A3352-1UN | 04061833627648 |