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A3352
Acyl-Coenzym A-Synthetase aus Pseudomonas sp.
≥2 units/mg protein
Synonym(e):
Acid: CoA ligase (AMP-forming)
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About This Item
Empfohlene Produkte
Form
powder
Qualitätsniveau
Spezifische Aktivität
≥2 units/mg protein
Versandbedingung
dry ice
Lagertemp.
−20°C
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Allgemeine Beschreibung
Acyl-coenzyme A synthetase belongs to adenylate-forming enzymes superfamily. It has a conserved adenosine triphosphate/adenosine monophosphate (ATP/AMP) binding motif.
Anwendung
Acyl-coenzyme A (coA) synthetase from Pseudomonas sp. has been used:
- as ligase in the synthesis of mevalonate derivatives of adenosine triphosphate (ATP)
- in in vitro fatty acylation assays
- in the synthesis of (14C)Vernoloyl-CoA (Va-CoA),(3) bisphosphonates derivatives of ATP(4) and (3H)Palmitate-CoA
Acyl-coenzyme A Synthetase may be used to study fatty acid metabolism and lipid metabolism. It has been used to study its interaction with fatty acid transport proteins, which has been found to be involved in the efficient cellular uptake of long-chain fatty acids in adipocytes .
Biochem./physiol. Wirkung
Acyl coenzyme A synthetase proteins are involved in regulating and facilitating long-chain fatty acid transport in mammalian cells .
Acyl-coenzyme A (CoA) synthetase (ACS) enzyme catalyzes a two-step thioesterification reaction involving the conversion of free fatty acids (FAs) to CoA esters. The substrate for ACS varies from two carbon to 26 carbon FAs. It is involved in the activation of FAs for lipid metabolism and enables FA to participate in various cellular metabolic pathways.
Einheitendefinition
1 U bildet 1.0 μmol AMP und Oleoyl-Coenzym A aus ATP und Oleat bei pH 8.1 und 25 °C in Anwesenheit von Coenzym A.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Physiological role of acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa
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Nature cell biology, 13(10), 1189-1201 (2011-09-20)
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The Journal of Biological Chemistry, 292(33), 13507-13513 (2017)
Michael Veit et al.
Methods in molecular biology (Clifton, N.J.), 446, 163-182 (2008-04-01)
Palmitoylation or S-acylation is the post-translational attachment of fatty acids to cysteine residues and is common among integral and peripheral mem brane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as
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