Skip to Content
Merck
HomeProductsMolecular Biology & Functional GenomicsGene Editing & Functional Genomics

Gene Editing & Functional Genomics

The image presents a close-up view of virus particles, with a dominant golden particle in the center, characterized by its spherical shape and numerous spike proteins. The background features additional particles in golden-yellow and blue hues, all set against a blurred backdrop that accentuates the central figure and adds depth to the composition. The image captures the intricate details and diversity of virus particles, highlighting their unique structures.

Sigma-Aldrich® Advanced Genomics offers a complete suite of genome engineering and modulation products and services. Our comprehensive portfolio delivers support for every step of your research, from discovery through translational research to therapeutic impact.  

Target a single gene or screen a whole genome with fully customizable products. With tools to edit using CRISPR or ZFNs, modulate expression with CRISPRa/i or RNAi, or perform whole genome screens, you’re limited only by your scientific curiosity. And with over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics offers an unsurpassed breadth of expertise and intellectual property to help you succeed.

View All Products

Explore by Category

CRISPR & Gene EditingRNAi Single ClonesGenetic ScreeningRNAi Libraries
CRISPR & Gene Editing

CRISPR & Gene Editing

With decades of gene editing experience and an unsurpassed portfolio of CRISPR and ZFN technology patents, Sigma-Aldrich® Advanced Genomics delivers the highest quality reagents for your entire workflow, from early-stage discovery to translational research. Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench.

View Products

RNAi Single Clones

Sigma-Aldrich® Advanced Genomics RNAi Single Clones deliver powerful, long term, and stable gene silencing. As an exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC), our comprehensive offering consists of nearly 200,000 pre-cloned shRNA constructs targeting more than 22,500 human and 20,000 mouse genes.

View Products
RNAi Single Clones

Explore More Categories

The image showcases a close-up view of a multi-well plate being filled with a red liquid by an automated pipetting system. The pipettes are aligned and dispensing the liquid into the wells in unison, with a blurred background emphasizing the precision of the process. This scene is typical in laboratory settings where multiple samples are processed simultaneously for experiments or testing.
Genetic Screening

Sigma-Aldrich® Advanced Genomics offers complete solutions for your genetic screens at any scale. Whether you're targeting specific genes or performing a genome-wide screen, we offer extensive pooled and arrayed formats to meet your needs. From gene expression knockdown with CRISPRi and RNAi to overexpression with CRISPRa and ORF, we have everything you need for your target discovery research.

View Products
The image presents a close-up view of virus particles, with a dominant golden particle in the center, characterized by its spherical shape and numerous spike proteins. The background features additional particles in golden-yellow and blue hues, all set against a blurred backdrop that accentuates the central figure and adds depth to the composition. The image captures the intricate details and diversity of virus particles, highlighting their unique structures.
RNAi Libraries

Sigma-Aldrich® Advanced Genomics is the exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC). These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. Available in standard glycerol format or higher quality DNA and lentiviral formats.

View Products
Related Product Categories
Oligos, qPCR Probes & Peptides
Choose custom products from our comprehensive portfolio of DNA and RNA oligos, qPCR probes and peptides as we offer numerous options for manufacturing platforms, purity levels, modifications to meet a variety of research applications.
Roche Life Science Products
Roche Life Science Products provide dependable reagents for breakthrough research, ensuring high-quality, reproducible results.
NGS Library Preparation
Prepare your library for next-gen sequencing. Isolate, fragment, repair, and link nucleic acids with adapters using ligation or tagmentation methods. Essential step before DNA/RNA sequencing.
Epigenetics
Epigenetic reagents and resources for investigating RNA species, DNA methylation, chromatin modifications, and histone modifications.
PCR & Amplification
PCR reagents, kits, whole genome amplification, PCR consumables, and thermocyclers for your PCR workflow needs.
Microbiome
Comprehensive Gut Microbiome Analysis: Uncover a holistic solution encompassing sample prep, sequencing, bioinformatics, and statistics. From 16S to WGS.
Nucleic Acid Purification
DNA and RNA extraction, purification, and reaction clean-up reagents and kits.
Cloning & Expression
Explore our comprehensive offering of restriction enzymes, protein expression vectors, transfection reagents and protein expression technologies for your molecular cloning and protein expression workflow needs.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?