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A2647

Sigma-Aldrich

Adenosin-5′-(β,γ-imido)triphosphat Tetralithiumsalz Hydrat

≥93% (HPLC), powder

Synonym(e):

βγ-Imidoadenosin-5′-triphosphat Tetralithiumsalz, AMP-PNP, ATP[β,γ-NH], Adenylyl-imidodiphosphat Tetralithiumsalz, App(NH)p

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About This Item

Empirische Formel (Hill-System):
C10H17N6O12P3 · xLi+ · yH2O
CAS-Nummer:
25612-73-1
Molekulargewicht:
506.20 (free acid basis)
Beilstein:
6047109
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24890685
NACRES:
NA.51

Biologische Quelle

natural (organic)

Qualitätsniveau

200

Assay

≥93% (HPLC)

Form

powder

Farbe

white

Löslichkeit

H2O: 50 mg/mL

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1

InChIKey

PVKSNHVPLWYQGJ-KQYNXXCUSA-N

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Anwendung

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.

Biochem./physiol. Wirkung

A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.

Vorsicht

AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate.

Rekonstituierung

A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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P Gayathri et al.
Science (New York, N.Y.), 338(6112), 1334-1337 (2012-11-01)
To ensure their stable inheritance by daughter cells during cell division, bacterial low-copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of the Escherichia coli R1 plasmid, ParM, an
Vladimir M Korkhov et al.
Nature, 490(7420), 367-372 (2012-09-25)
The ATP-binding cassette (ABC) transporter BtuCD mediates the uptake of vitamin B(12) across the inner membrane of Escherichia coli. Previous structures have shown the conformations of apo states, but the transport mechanism has remained unclear. Here we report the 3.5 Å
Timothy O Street et al.
Molecular cell, 42(1), 96-105 (2011-04-09)
Hsp90 is a ubiquitous molecular chaperone. Previous structural analysis demonstrated that Hsp90 can adopt a large number of structurally distinct conformations; however, the functional role of this flexibility is not understood. Here we investigate the structural consequences of substrate binding
Ya-Nan Xu et al.
Nucleic acids research, 40(19), 9802-9814 (2012-08-14)
Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not
Bryan H Schmidt et al.
Nature structural & molecular biology, 19(11), 1147-1154 (2012-10-02)
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