A0835

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

• Synonym(e): Ac-DEVD-CHO
• Empirische Formel (Hill-System): C₂₀H₃₀N₄O₁₁
• CAS-Nummer: 169332-60-9
• Molekulargewicht: 502.47
• MDL-Nummer: MFCD00671412
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24890193
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Farbe: white
• Löslichkeit: H₂O: 1 mg/mL
• Lagertemp.: −20°C
• SMILES String: [H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
• InChI: 1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)
• InChIKey: UMBVAPCONCILTL-UHFFFAOYSA-N
• Angaben zum Gen: human ... CASP1(834) , CASP3(836) , CASP7(840) , CASP8(841)

Beschreibung

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

Allgemeine Beschreibung

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Anwendung

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Biochem./physiol. Wirkung

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)