39488
Pyrimidinnukleosidphosphorylase
recombinant, expressed in E. coli, ≥1300 U/mL
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CAS-Nummer:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Specific activity:
≥1300 U/mL
Recombinant:
expressed in E. coli
Technischer Dienst
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Unterstützung erhaltenrecombinant
expressed in E. coli
Quality Level
form
liquid
specific activity
≥1300 U/mL
relevant disease(s)
cancer
storage temp.
−20°C
Application
Pyrimidine nucleoside phosphorylase (PyNPase) may be used as a marker to predict the malignant potential of breast cancer, especially lymph node metastasis. PyNPase is used to study breast cancer, specifically its role in angiogenesis.
Biochem/physiol Actions
Pyrimidine nucleoside phosphorylase (PyNPase) is a glycosyltransferase that catalyzes the conversion of pyrimidine nucleoside and phosphate to a pyrimidine base and α-D-ribose 1-phosphate. PyNPase plays a significant role in breast cancer angiogenesis.
Other Notes
One unit will convert 1 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per minute at pH 7.4 and 25°C
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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K Mimori et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 10(1), 111-113 (1999-03-17)
The clinical significance of pyrimidine nucleoside phosphorylase (PyNPase) activity in breast carcinomas has never been determined. In 41 cases of breast carcinoma, the enzyme activity of PyNPase was determined by the high performance liquid chromatography (HPLC) assay and its value
M J Pugmire et al.
Structure (London, England : 1993), 6(11), 1467-1479 (1998-11-18)
Pyrimidine nucleoside phosphorylase (PYNP) catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway. In lower organisms (e.g. Bacillus stearothermophilus) PYNP accepts both thymidine and uridine, whereas in mammalian and other higher organisms it is specific for thymidine
T Hamamoto et al.
Bioscience, biotechnology, and biochemistry, 60(7), 1179-1180 (1996-07-01)
The purine nucleoside phosphorylase (Pu-NPase) and the pyrimidine nucleoside phosphorylase (Py-NPase) have been purified from Bacillus stearothermophilus TH 6-2. The Pu-NPase is a trimer of 30-kDa subunits and the Py-NPase is a dimer of 46-kDa subunits. The isoelectric points of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| CDS003547-250MG | 04061828966479 |
| 39488-1ML | 04061838082428 |
| 39488-5ML | 04061838082435 |