PHR1224

Aminocapronsäure

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 6-Amino-hexansäure, ε-Amino-capronsäure, 6-Aminocapronsäure, EACA
• Lineare Formel: H₂N(CH₂)₅CO₂H
• CAS-Nummer: 60-32-2
• Molekulargewicht: 131.17
• Beilstein: 906872
• EG-Nummer: 200-469-3
• MDL-Nummer: MFCD00008238
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823230
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to Ph. Eur. A0420000; traceable to USP 1021000
• API-Familie: aminocaproic acid
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 207-209 °C (dec.) (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-30°C
• SMILES String: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChIKey: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• Angaben zum Gen: human ... PLAT(5327) , PLG(5340)

Beschreibung

Allgemeine Beschreibung

Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Aminocaproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry and in bulk and injectable forms using colorimetric method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Lysin analog. Fördert die rasche Dissoziation von Plasmin, wodurch die Aktivierung von Plasminogen und in der Folge die Fibrinolyse inhibiert werden.^1,2 Es wurde berichtet, dass 6-Amino-capronsäure die Bindung von Plasminogen an aktivierte Plättchen inhibiert. ³ Ein früher Bericht gibt an, dass sie die Aktivierung der ersten Komponente des Komplementärsystems inhibiert.⁴ Bindet an Carboxypeptidase B und inaktiviert sie. ⁵

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA9036 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable