PHR1131

(±)-Verapamil -hydrochlorid

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 5-[N-(3,4-Dimethoxyphenylethyl)-methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitril -hydrochlorid
• Lineare Formel: (CH₃O)₂C₆H₃CH₂CH₂N(CH₃)(CH₂)₃C[C₆H₃(OCH₃)₂][CH(CH₃)₂]CN · HCl
• CAS-Nummer: 152-11-4
• Molekulargewicht: 491.06
• Beilstein: 3647093
• EG-Nummer: 205-800-5
• MDL-Nummer: MFCD00055208
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823152
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to Ph. Eur. V0100000; traceable to USP 1711202
• API-Familie: verapamil
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 142 °C (dec.) (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-30°C
• SMILES String: Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• InChIKey: DOQPXTMNIUCOSY-UHFFFAOYSA-N
• Angaben zum Gen: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Verapamil hydrochloride is a calcium channel blocker used commonly for the management of angina, supra-ventricular tachyarrhythmia, hypertension, migraine and atrial tachyarrhythmias.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Verapamil hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in drug raw material and pharmaceutical formulations by high performance liquid chromatography and spectrophotometric method, respectively.

Biochem./physiol. Wirkung

α₁-Adrenozeptor-Antagonist, L-Typ-Calcium-Kanal-Blocker. Hemmt L-type Ca²⁺-Kanäle in glatter und Herzmuskulatur, induziert in vitro Apoptose von humanen primären und metastatischen Kolonadenokarzinom-Zellen. Erhöht basale ATPase-Aktivität von Pgp. Substrat von CYP3A4 und CYP2C6.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA5980 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301,H411
• P-Sätze: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral - Aquatic Chronic 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable