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Merck

PHR1028

Supelco

1,4-Benzochinon

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

p-Benzochinon, Chinon

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About This Item

Lineare Formel:
C6H4(=O)2
CAS-Nummer:
Molekulargewicht:
108.09
Beilstein:
773967
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352005
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1056504

Dampfdichte

3.73 (vs air)

Dampfdruck

0.1 mmHg ( 25 °C)

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

815 °F

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

113-115 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

O=C1C=CC(=O)C=C1

InChI

1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H

InChIKey

AZQWKYJCGOJGHM-UHFFFAOYSA-N

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Allgemeine Beschreibung

1,4-Benzoquinone is a cyclic conjugated diketone. It belongs to the class of quinones, naturally occurring in plants, fungi, and bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB7811 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Sol. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Flammpunkt (°F)

170.6 °F - closed cup

Flammpunkt (°C)

77 °C - closed cup


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Slide 1 of 4

1 of 4

Quinone chemistry and toxicity
Monks JT, et al.
Toxicology and Applied Pharmacology, 112(1), 2-16 (1992)
Takafumi Hasegawa et al.
Journal of neurochemistry, 87(2), 470-475 (2003-09-27)
Oxidized metabolites of dopamine, known as dopamine quinone derivatives, are thought to play a pivotal role in the degeneration of dopaminergic neurons. Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme
Vandana Bhalla et al.
Dalton transactions (Cambridge, England : 2003), 42(13), 4464-4469 (2013-02-16)
The binding behavior of nanoaggregates of pentacenequinone derivative 1 having thiophene groups has been investigated toward various cations (Fe(3+), Fe(2+), Pd(2+), Mg(2+), Cd(2+), Hg(2+), Ni(2+), Zn(2+), Cu(2+), Pb(2+), Co(2+), K(+), Na(+) and Li(+)) using UV-vis and fluorescence spectroscopy. Among the
S Saif Hasan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4297-4302 (2013-02-27)
As much as two-thirds of the proton gradient used for transmembrane free energy storage in oxygenic photosynthesis is generated by the cytochrome b6f complex. The proton uptake pathway from the electrochemically negative (n) aqueous phase to the n-side quinone binding
K He et al.
Biochemical pharmacology, 62(2), 191-198 (2001-06-08)
Oxidative ring opening of troglitazone (TGZ)(1) a thiazolidine 2,4-dione derivative used for the treatment of type II diabetes mellitus, leads to the formation of a quinone metabolite. The formation of TGZ quinone was shown to be NADPH dependent and to

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