N5410

Nicotinsäure

meets USP testing specifications

• Synonym(e): 3-Picolinsäure, Niacin, Pellagra Präventivfaktor, Pyridin-3-carbonsäure, Vitamin B₃
• Empirische Formel (Hill-System): C₆H₅NO₂
• CAS-Nummer: 59-67-6
• Molekulargewicht: 123.11
• Beilstein: 109591
• EG-Nummer: 200-441-0
• MDL-Nummer: MFCD00006391
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24897734
• NACRES: NA.21

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Agentur: USP/NF; meets USP testing specifications
• Assay: 99.0-101.0% dry basis
• Form: powder
• Farbe: white
• mp (Schmelzpunkt): 236-239 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChIKey: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Beschreibung

Allgemeine Beschreibung

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Anwendung

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Biochem./physiol. Wirkung

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): 379.4 °F - closed cup
• Flammpunkt (°C): 193 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves