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33864

Supelco

Tilmicosin

VETRANAL®, analytical standard, mix of isomers

Synonym(e):

20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)-desmycosin

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About This Item

Empirische Formel (Hill-System):
C46H80N2O13
Molekulargewicht:
869.13
MDL-Nummer:
MFCD19705582
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329754677
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Produktlinie

VETRANAL®

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

CC1OC(OCC(C(CC)O2)/C=C(/C=C/C(C(C)CC(CCN3CC(C)CC(C)C3)C(OC4OC(C)C(O)C(N(C)C)C4O)C(C)C(O)CC2=O)=O)C)C(OC)C(OC)C1O

InChI

1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1

InChIKey

JTSDBFGMPLKDCD-XVFHVFLVSA-N

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Allgemeine Beschreibung

Tilmicosin is a semisynthetic macrolide antibiotic, with broad spectrum activity towards Mycoplasma spp., Pasteurella spp., and various gram-positive organisms in animals.

Anwendung

Verordnung (EU) Nr. 37/2010 vom 22. Dezember 2009 über pharmakologisch wirksame Stoffe und ihre Einstufung hinsichtlich der Rückstandshöchstmengen in Lebensmitteln tierischen Ursprungs
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tilmicosin may be used as a reference standard for the determination of the analyte in chicken, swine, cattle, sheep tissues and milk samples using liquid chromatography with ultraviolet detection (LC-UV).

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Zielorgane

Cardio-vascular system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCG2736
BCCD7299
BCCB4507
BCBV4513
BCBT8086

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Tylosin potency: ≥800 units/mg tylosin

Sigma-Aldrich

T6134

Tylosin

Shuyu Xie et al.
Particle and fibre toxicology, 8, 33-33 (2011-11-22)
Our previous studies demonstrated that tilmicosin-loaded hydrogenated castor oil solid lipid nanoparticles (Til-HCO-SLN) are a promising formulation for enhanced pharmacological activity and therapeutic efficacy in veterinary use. The purpose of this work was to evaluate the acute toxicity of Til-HCO-SLN.
Determination of tilmicosin residues in cow and sheep milk by liquid chromatography.
Stobba-Wiley.MC and Readnour.SR
Journal of AOAC (Association of Official Analytical Chemists) International, 83(3), 555-562 (2000)
Xinxin Ci et al.
Immunopharmacology and immunotoxicology, 33(4), 626-632 (2011-03-25)
Tilmicosin, a semi-synthetic tylosin-derived macrolide antibiotic commonly used by veterinarians, has been shown to possess anti-inflammatory activity. However, possible use in asthma treatment has not yet been studied. In this study, we investigated the anti-inflammatory properties of tilmicosin using a
X F Wang et al.
Veterinary journal (London, England : 1997), 191(1), 115-120 (2011-09-09)
This study aimed to enhance the antibacterial activity of tilmicosin by solid lipid nanoparticles (SLN). Tilmicosin-loaded hydrogenated castor oil (HCO)-SLN was prepared using a hot homogenisation and ultrasonication method. The physicochemical characteristics of SLN were investigated by scanning electron microscopy
Dapeng Peng et al.
Journal of agricultural and food chemistry, 60(1), 44-51 (2011-12-06)
Incorrect use of tylosin and tilmicosin could result in allergy and select resistance. To monitor the illegal use of these antibiotics in animals, a monoclonal-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) has been established. Several haptens were synthesized and conjugated
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