MAB3731

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

clone 6AT1877, Chemicon^®, from mouse

• Synonym(e): c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 6AT1877, monoclonal
• Speziesreaktivität: human, mouse
• Hersteller/Markenname: Chemicon^®
• Methode(n): ELISA: suitable
• Isotyp: IgG1
• NCBI-Hinterlegungsnummer: NM_000245.2
• UniProt-Hinterlegungsnummer: P08581
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: phosphorylation (pTyr1234/pTyr1235)
• Angaben zum Gen: human ... MET(4233) ; mouse ... Met(17295)

Beschreibung

Spezifität

Reacts with Met/HGFR (Hepatocyte growth factor receptor) only when phosphorylated at Tyr1234 and Tyr1235. The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for Met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.

Immunogen

Epitope: phospho-specific (Tyr1234/1235)

Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/1235 of human Met.

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Wachstumsfaktoren & -rezeptoren

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.

ELISA (direct): 1:1,000

Optimal working dilutions must be determined by the end user.

Physikalische Form

Format: Purified

Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.

Lagerung und Haltbarkeit

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable