AB1892

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, NT

Chemicon^®, from rabbit

• Synonym(e): CX3CR1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: rat, human, mouse
• Hersteller/Markenname: Chemicon^®
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NM_001337.3
• UniProt-Hinterlegungsnummer: P49238
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CX3CR1(1524)

Beschreibung

Allgemeine Beschreibung

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.

Spezifität

Specific for human C-X-X-X-C Chemokine Receptor 1 (CX3CR1) at the Extracellular loop. The sequence is identical to that of rat and differs from that of mouse by only one amino acid.

Immunogen

Epitope: N-terminus

Synthetic peptide from the N-terminal of human CX3CR1.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Cytokine & Cytokin-Rezeptoren

Detect C-X-X-X-C Chemokine Receptor 1 using this Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, N-terminus validated for use in IH & WB.

Western blot: 1:500 - 1:2000 (Human spleen tissue lysate can be used as positive control and an approximately 50 kDa band can be detected)

Immunohistochemistry in frozen sections

Optimal working dilutions must be determined by end user.

Physikalische Form

Format: Purified

Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.

Lagerung und Haltbarkeit

Store at 2-8°C for up to 12 months.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable