AB15558

Anti-Somatostatin Receptor Type 2 Antibody

• UNSPSC Code: 12352203
• NACRES: NA.43
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: -

Eigenschaften

• conjugate: unconjugated
• Quality Level: 100
• antibody form: purified antibody
• clone: polyclonal
• purified by: (ImmunoAffinity Purified)
• species reactivity: rat, mouse, rabbit
• technique(s): immunohistochemistry: suitable, western blot: suitable
• UniProt accession no.: Q92796
• target post-translational modification: unmodified

Beschreibung

General description

FUNCTION: SwissProt: Q92796 # Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
SIZE: 817 amino acids; 90344 Da
SUBUNIT: Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3.
DISEASE: SwissProt: Q92796 # Defects in DLG3 are the cause of non-syndromic mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
SIMILARITY: SwissProt: Q92796 ## Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 3 PDZ (DHR) domains. & Contains 1 SH3 domain.

Purified peptide from the N-terminus of rat Somatostatin Receptor Type 2 (Accession number P30680).

Application

Western blot: 1:200-1:500 using ECL on rat brain and pancreas lysate.
Dilutions should be made using a carrier protein such as BSA (1-3%).

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes Somatostatin Receptor Type 2 (SSTR2).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).

Preparation Note

Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Other Notes

Included free of charge with the antibody is 40 µg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 µL of sterile deionized water. For negative control, preincubate 1 µg of peptide with 1 µg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.

The immunogen sequence is 12 of 15 amino acids identical in human and porcine.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids