8.01949

N-Bromosuccinimide

for peptide synthesis

• Synonym(e): N-Bromosuccinimide, NBS
• Empirische Formel (Hill-System): C₄H₄BrNO₂
• CAS-Nummer: 128-08-5
• Molekulargewicht: 177.98
• MDL-Nummer: MFCD00005510
• UNSPSC-Code: 12352115
• EG-Index-Nummer: 204-877-2
• NACRES: NA.22

Eigenschaften

• product name: N-Bromosuccinimide, for synthesis
• Dampfdruck: 14.8 hPa ( 20 °C)
• Qualitätsniveau: 200
• Form: powder
• Wirksamkeit: >2000 mg/kg LD₅₀, oral (Rat)
• Eignung der Reaktion: reagent type: oxidant
• mp (Schmelzpunkt): 174-179 °C
• Löslichkeit: 14.8 g/L (decomposition)
• Dichte: 2.1 g/cm³ at 20 °C
• Schüttdichte: 750 kg/m³
• Lagertemp.: 2-8°C
• InChI: 1S/C4H4BrNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
• InChIKey: PCLIMKBDDGJMGD-UHFFFAOYSA-N

Beschreibung

Anwendung

• Mechanistic study on iodine-catalyzed aromatic bromination of aryl ethers by N-bromosuccinimide: This study explores the roles of NBS in organic synthesis, particularly in radical and electrophilic substitutions (Pramanick et al., 2017).
• One‐Pot Protocol for the Synthesis of Imidazoles and Quinoxalines using N‐Bromosuccinimide: This paper reports a green, efficient synthesis of heterocycles mediated by NBS (Pardeshi et al., 2017).
• N-Bromosuccinimide as an Interfacial Alleviator for Br/I Exchange in Perovskite for Solar Cell Fabrication: This research demonstrates the use of NBS in improving the crystallization and defect passivation in perovskite solar cells (Pegu et al., 2021).
• N‐Bromosuccinimide‐Mediated Radical Cyclization of 3‐Arylallyl Azides: Synthesis of 3‐Substituted Quinolines: Discusses the application of NBS under visible light irradiation to synthesize quinolines (Wang et al., 2015).
• N-Bromosuccinimide mediated synthesis of triazatruxenes from indoles: This study highlights the cyclotrimerization of indoles using NBS, demonstrating its utility as a reagent in complex organic transformations (Toworakajohnkun et al., 2017).

Hinweis zur Analyse

Gehalt (iodometrisch): ≥ 99.0 %
Identität (IR): entspricht

Sicherheitshinweise

• Piktogramme: GHS03,GHS05,GHS07,GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H272 - H290 - H315 - H317 - H319 - H341 - H400
• P-Sätze: P210 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Aquatic Acute 1 - Eye Irrit. 2 - Met. Corr. 1 - Muta. 2 - Ox. Sol. 3 - Skin Irrit. 2 - Skin Sens. 1B
• Lagerklassenschlüssel: 5.1B - Oxidizing hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable