203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).

• Synonym(e): bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
• Lineare Formel: K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (⁵¹V-NMR)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow to orange
• Löslichkeit: water: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

A potent inhibitor of phosphotyrosine phosphatase activity (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
phosphotyrosine phosphatase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 18 nM against PTEN

Target K_i: 100 nM for phosphotyrosine phosphatase

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Unstable in solution; reconstitute just prior to use.

Sonstige Hinweise

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable