171601

Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(e): Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
• Empirische Formel (Hill-System): C₇₃H₁₁₈N₁₆O₂₇
• Molekulargewicht: 1651.81
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: lyophilized
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Löslichkeit: aqueous buffer, pH 7.5: 1 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC₅₀ = 30 nM).

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
APP

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM against amyloid precursor protein (APP) β-secretase

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

Physikalische Form

Supplied as a trifluoroacetate salt.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Sinha, S., et al. 1999. Nature 402, 537.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable