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05-916

Sigma-Aldrich

Anti-P-Cadherin Antibody, clone 6A9

ascites fluid, clone 6A9, Upstate®

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43

Biologische Quelle

mouse

Qualitätsniveau

Antikörperform

ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

6A9, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CDH3(1001)

Spezifität

Recognizes P-Cadherin

Immunogen

P-Cadherin extracellular domain purified from A431 cell membranes.

Anwendung

This Anti-P-Cadherin Antibody, clone 6A9 is validated for use in IP, WB, IC for the detection of P-Cadherin.

Qualität

Routinely evaluated by immunoblot on A431 cell lysates.

Zielbeschreibung

Mr 120kDa

Hinweis zur Analyse

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for minigels.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1


Analysenzertifikate (COA)

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Differential displacement of classical cadherins by VE-cadherin
Jaggi, M., et al
Cell communication & adhesion, 9, 103-115 (2002)
M D Hines et al.
Journal of cell science, 112 ( Pt 24), 4569-4579 (1999-11-27)
Cadherin function is required for normal keratinocyte intercellular adhesion and stratification. In the present study, we have investigated whether cadherin-cadherin interactions may also modulate keratinocyte differentiation, as evidenced by alterations in the levels of several differentiation markers. Confluent keratinocyte cultures
Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
Lewis, J. E., et al
The Journal of Investigative Dermatology, 102, 870-877 (1994)
M T Nieman et al.
Journal of cell science, 112 ( Pt 10), 1621-1632 (1999-04-23)
The cadherin/catenin complex mediates Ca2+-dependent cell-cell interactions that are essential for normal developmental processes. It has been proposed that sorting of cells during embryonic development is due, at least in part, to expression of different cadherin family members or to
K A Knudsen et al.
Human pathology, 31(8), 961-965 (2000-09-15)
Breast cancers often show reduced expression of the transmembrane cell-cell adhesion protein, E-cadherin. In addition, approximately half of breast carcinomas express P-cadherin, which correlates with poor survival. A large fragment of the E-cadherin extracellular domain can be detected in serum

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